AustralieFrV1, Main, Exploration, bibRecord, 007E50

Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors

Identifieur interne : 007E50 ( Main/Exploration ); précédent : 007E49; suivant : 007E51

Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors

Auteurs : Florence Netzer [France] ; Nathalie Mandjee [France] ; Anthony J. Verberne [Australie] ; Jean-François Bernard [France] ; Michel Hamon [France] ; Raul Laguzzi [France] ; Caroline Sévoz-Couche [France]

Source :

European Journal of Neuroscience [ 0953-816X ] ; 2009-05.

RBID : ISTEX:E74A09295241189012A76074C57829DEB3126CBE

English descriptors

Abstract

Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT3, NK1 and GABAA receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT3 receptor antagonist), bicuculline (a GABAA receptor antagonist) and GR‐205171 (an NK1 receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT3 receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT3, GABAA and NK1 receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.

Url:

https://api.istex.fr/document/E74A09295241189012A76074C57829DEB3126CBE/fulltext/pdf

DOI: 10.1111/j.1460-9568.2009.06758.x

Affiliations:

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<term>Baroreceptor</term>
<term>Baseline</term>
<term>Bezold</term>
<term>Bicuculline</term>
<term>Bilateral microinjections</term>
<term>Blackwell publishing</term>
<term>Blood pressure</term>
<term>Bradycardia</term>
<term>Bradycardic</term>
<term>Bradycardic component</term>
<term>Bradycardic response</term>
<term>Bradycardic responses</term>
<term>Cardiac</term>
<term>Cardiac responses</term>
<term>Cardiopulmonary</term>
<term>Cardiovagal</term>
<term>Cardiovascular</term>
<term>Carotid</term>
<term>Carotid chemoreceptor</term>
<term>Central microinjections</term>
<term>Chemical stimulation</term>
<term>Chemoreceptor</term>
<term>Defence</term>
<term>Defence reaction</term>
<term>Dlpag</term>
<term>Dlpag activation</term>
<term>Dlpag stimulation</term>
<term>Electrical stimulation</term>
<term>European journal</term>
<term>European neuroscience societies</term>
<term>Experimental responses</term>
<term>Gabaa</term>
<term>Gabaa receptors</term>
<term>Gabaergic</term>
<term>Granisetron</term>
<term>Hamon</term>
<term>Inhibition</term>
<term>Inhibitory</term>
<term>Inhibitory effect</term>
<term>Inhibitory effects</term>
<term>Jarisch</term>
<term>Journal compilation federation</term>
<term>Laguzzi</term>
<term>Lateral</term>
<term>Medullary</term>
<term>Microinjection</term>
<term>Microinjections</term>
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<term>Netzer</term>
<term>Neuron</term>
<term>Neuroscience</term>
<term>Nucleus tractus solitarii</term>
<term>Nucleus tractus solitarius</term>
<term>Paton</term>
<term>Periaqueductal</term>
<term>Phenylbiguanide</term>
<term>Physiol</term>
<term>Pmol</term>
<term>Receptor</term>
<term>Receptor antagonist</term>
<term>Receptor antagonists</term>
<term>Region neurons</term>
<term>Same rats</term>
<term>Separate groups</term>
<term>Serotonergic</term>
<term>Serotonergic neurons</term>
<term>Sevoz</term>
<term>Solitarii</term>
<term>Solitary tract</term>
<term>Tractus</term>
<term>Vagal</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Activation</term>
<term>Afferent</term>
<term>Baroreceptor</term>
<term>Baseline</term>
<term>Bezold</term>
<term>Bicuculline</term>
<term>Bilateral microinjections</term>
<term>Blackwell publishing</term>
<term>Blood pressure</term>
<term>Bradycardia</term>
<term>Bradycardic</term>
<term>Bradycardic component</term>
<term>Bradycardic response</term>
<term>Bradycardic responses</term>
<term>Cardiac</term>
<term>Cardiac responses</term>
<term>Cardiopulmonary</term>
<term>Cardiovagal</term>
<term>Cardiovascular</term>
<term>Carotid</term>
<term>Carotid chemoreceptor</term>
<term>Central microinjections</term>
<term>Chemical stimulation</term>
<term>Chemoreceptor</term>
<term>Defence</term>
<term>Defence reaction</term>
<term>Dlpag</term>
<term>Dlpag activation</term>
<term>Dlpag stimulation</term>
<term>Electrical stimulation</term>
<term>European journal</term>
<term>European neuroscience societies</term>
<term>Experimental responses</term>
<term>Gabaa</term>
<term>Gabaa receptors</term>
<term>Gabaergic</term>
<term>Granisetron</term>
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<term>Inhibitory effects</term>
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<term>Neuron</term>
<term>Neuroscience</term>
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<front><div type="abstract" xml:lang="en">Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT3, NK1 and GABAA receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT3 receptor antagonist), bicuculline (a GABAA receptor antagonist) and GR‐205171 (an NK1 receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT3 receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT3, GABAA and NK1 receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.</div>
</front>
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<name sortKey="Bernard, Jean Rancois" sort="Bernard, Jean Rancois" uniqKey="Bernard J" first="Jean-François" last="Bernard">Jean-François Bernard</name>
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<name sortKey="Sevoz Ouche, Caroline" sort="Sevoz Ouche, Caroline" uniqKey="Sevoz Ouche C" first="Caroline" last="Sévoz-Couche">Caroline Sévoz-Couche</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Verberne, Anthony J" sort="Verberne, Anthony J" uniqKey="Verberne A" first="Anthony J." last="Verberne">Anthony J. Verberne</name>
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Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors

Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri